Molecular and Spatial Mapping of Bladder Nociceptors During Development and Maturation

Grant number: 1U01DK101029 | Funding period: 2013 - 2015

Completed

Abstract

DESCRIPTION (provided by applicant): Pelvic pain conditions are debilitating and treatment options limited. A major issue contributing to this problem is the relative lack of understanding o factors underlying persistent visceral pain conditions - a much larger research effort exists in th area of somatic pain (e.g., pain of skin, skeletal muscle, bone origin). The goal of this nGUDMAP molecular anatomy project is to map the primary structural and molecular features of a major population of nociceptor neurons that innervate the urinary bladder of the mouse. This project is relevant to genitourinary pain, such as interstitial cystitis/painful bladder syndrome. The experiments will focus on no..

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University of Melbourne Researchers